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Bone morphogenetic protein (BMP) inhibits neural specification and induces epidermal differentiation during ectodermal patterning. However, the mechanism of this process is not well understood.
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Lung cancer patients with EGFR mutations were enrolled in the study in the period from June 2005 to June 2012. Clinical factors were collected including sex, age, and smoking status. In the patients with EGFR mutations, 18 patients provided sufficient tumor tissue specimens for further immunohistochemistry analyses.
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